首页> 外文OA文献 >STUDIES ON THE MECHANISM OF TUMOR INHIBITION BY L-ASPARAGINASE : EFFECTS OF THE ENZYME ON ASPARAGINE LEVELS IN THE BLOOD, NORMAL TISSUES, AND 6C3HED LYMPHOMAS OF MICE: DIFFERENCES IN ASPARAGINE FORMATION AND UTILIZATION IN ASPARAGINASE-SENSITIVE AND -RESISTANT LYMPHOMA CELLS
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STUDIES ON THE MECHANISM OF TUMOR INHIBITION BY L-ASPARAGINASE : EFFECTS OF THE ENZYME ON ASPARAGINE LEVELS IN THE BLOOD, NORMAL TISSUES, AND 6C3HED LYMPHOMAS OF MICE: DIFFERENCES IN ASPARAGINE FORMATION AND UTILIZATION IN ASPARAGINASE-SENSITIVE AND -RESISTANT LYMPHOMA CELLS

机译:L-天冬酰胺酶抑制肿瘤机制的研究:酶对小鼠血液,正常组织和6C3H淋巴瘤中天冬酰胺水平的影响:天冬酰胺酶诱导的天冬酰胺形成和利用的差异。

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摘要

L-asparaginases of agouti serum and Escherichia coli cause a profound lowering in the level of free asparagine in the blood of treated mice and also in the tissues. During treatment, normal tissues and resistant 6C3HED lymphomas survive unharmed with intracellular asparagine levels which are critically low for sensitive lymphomas. An explanation for this contrast between the two types of lymphoma is provided by the finding that resistant cells have not only a higher asparagine synthetic capacity than sensitive cells but appear able to utilize endogenous asparagine preferentially for protein synthesis. Cell-free extracts of resistant cells contain an asparaginase synthetase, but this is not found in preparations from sensitive cells.
机译:刺鼠血清和大肠杆菌的L-天冬酰胺酶导致被治疗小鼠血液以及组织中游离天冬酰胺水平的显着降低。在治疗过程中,正常组织和耐药性6C3HED淋巴瘤可以存活,而对于敏感的淋巴瘤而言,细胞内的天冬酰胺水平极低。通过发现耐药细胞不仅比敏感细胞具有更高的天冬酰胺合成能力,而且似乎能够优先利用内源天冬酰胺进行蛋白质合成,从而为两种类型的淋巴瘤之间的这种差异提供了解释。抗性细胞的无细胞提取物包含天冬酰胺酶合成酶,但在敏感细胞的制剂中未发现。

著录项

  • 作者

    Broome, J. D.;

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  • 年度 1968
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  • 原文格式 PDF
  • 正文语种 {"code":"en","name":"English","id":9}
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